Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for the
treatment of broad-spectrum intractable diseases. However, its unfavorable properties such …

Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key
regulator of mitosis and programmed cell death. Initially, survivin was described as an …

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma of which at least a subset
arises from antigen-experienced B cells. However, what role antigen stimulation plays in its …

It is generally accepted that DNA predominantly exists in duplex form in cells. However,
under torsional stress imposed by active transcription, DNA can assume nonduplex …

Survivin, an inhibitor of apoptosis protein, is highly expressed in most cancers and
associated with chemotherapy resistance, increased tumor recurrence, and shorter patient …

ABT-737 and its orally active analog, ABT-263, are rationally designed inhibitors of BCL2
and BCL-XL. ABT-263 shows promising activity in early phase 1 clinical trials in B-cell …

Purpose To determine the maximum-tolerated dose (MTD) and assess the safety,
pharmacokinetics, and preliminary evidence of antitumor activity of YM155, a small …

Context: Currently there are no efficacious therapies for patients with anaplastic thyroid
carcinoma (ATC) that result in long-term disease stabilization or regression. Objective: We …

Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of
locally advanced disease generally requires various combinations of radiotherapy, surgery …

Survivin belongs to the family of apoptosis inhibitors (IAPs), which antagonizes the induction
of cell death. Dysregulated expression of IAPs is frequently observed in cancers, and the …