Over the last decade, the development and prevalence of obesity have posed a serious
public health risk, which has prompted studies on the regulation of adiposity. With the ease …

The Transforming Growth Factor-β (TGF-β) superfamily of signaling molecules plays critical
roles in development, differentiation, homeostasis, and disease. Due to the conservation of …

Diabetes mellitus (DM) is a metabolic disease characterized by a high blood sugar level that
can cause severe complications to the organism or even death when not treated. However …

In this study, we found that in the adipose tissue of wildtype animals, insulin and TGF‐β
signalling converge via a BMP antagonist short gastrulation (sog) to regulate ECM …

Craniofacial anomalies, especially midline facial defects, are among the most common birth
defects in patients and are associated with increased mortality or require lifelong treatment …

Splicing of precursor mRNA is an essential process for dividing cells, and splicing defects
have been linked to aging and various chronic diseases. Environmental stress has recently …

Smads and their transcription factor partners mediate the transcriptional responses of target
cells to secreted ligands of the transforming growth factor-β (TGF-β) family, including those …

Aging is a complex and highly regulated process of interwoven signaling mechanisms. As
an ancient transcriptional regulator of thermal adaptation and protein homeostasis, the Heat …

The CAP (cysteine-rich secretory proteins, antigen-5, and pathogenesis-related) proteins
are widely expressed and have been implicated to play diverse roles ranging from …

Intramuscular adipogenesis plays an important role in muscle development, which
determines the quality of goat meat. However, its underlying cellular and molecular …