Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases
such as coronary heart disease, cerebrovascular disease, and peripheral arterial disease …

Complement and Toll‐like receptors (TLR s) play key roles in the host immune response
and are swiftly activated by infection or other types of immunological stress. This review …

After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind
C5a and its des‐arginine form. As a heptahelical G protein‐coupled receptor but devoid of …

Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the
major contributor to the development and progression of cardiovascular diseases. Immune …

Background: Over the last decades, the role of inflammation and immune system activation
in the initiation and progression of coronary artery disease (CAD) has been established …

The biological significance of C5a receptor [(C5aR) 2/C5L2], a seven-transmembrane
receptor binding C5a and C5adesArg, remains ill-defined. Specific ligation of C5aR2 inhibits …

Cardiovascular diseases (CVD) remain the major cause of morbidity and mortality in
Europe. The clinical complications associated to arterial wall rupture involve intimal cap …

Neutrophil infiltration to ischemic tissues following reperfusion worsens injury. A key driver of
neutrophil recruitment and activation is the complement factor C5a, which signals through …

Atherosclerosis remains a ubiquitous and serious threat to human health. The initial
formation of the atherosclerotic lesion (atheroma) is driven by pro-inflammatory signaling …

Objective: Emerging evidence suggests that C3aR (C3a anaphylatoxin receptor) signaling
has protective roles in various inflammatory-related diseases. However, its role in …