Heterocyclic derivatives as a major group of organic compounds are enormously used for a
wide range of pharmaceutical and industrial applications. They are known for their biological …

Chemoresistance including intrinsic and acquired anticancer drug resistance continues to
be a primary hindrance towards curative cancer treatment. Therefore, deciphering the …

Purpose Despite advances in personalizing the efficacy of cancer therapy, our ability to
identify patients at risk of severe treatment side effects and provide individualized supportive …

Methotrexate (MTX) is a folic acid antagonist, the mechanism of action is to inhibit DNA
synthesis, repair and cell proliferation by decreasing the activities of several folate …

Introduction The number of umbrella reviews (URs) that compiled systematic reviews and
meta-analysis (SR-MAs) has increased dramatically over recent years. No formal guidance …

We examined the effect of protocatechuic acid (PCA) on methotrexate (MTX)‐induced
testicular and epididymal toxicity in Wistar rats, treated with MTX (20 mg/kg) alone or in …

Methotrexate (MTX), a structural analog of folic acid, is widely employed in the treatment of
different cancers and autoimmune diseases. Despite the successful results observed, the …

Background Oral mucositis (OM) is one of the main adverse effects of the chemotherapeutic
agent methotrexate (MTX). Aim To evaluate the relationship of OM with MTX metabolism …

Background Acute lymphoblastic leukemia (ALL) is the most common malignancy in
children, and methotrexate (MTX) is the key drug for ALL. Studies on the relationship …

Methotrexate is an antifolate agent used in the treatment of autoimmune diseases and
various types of cancers. It is a unique antiproliferative agent because it can be administered …