Function and therapeutic value of astrocytes in neurological diseases

HG Lee, MA Wheeler, FJ Quintana - Nature reviews Drug discovery, 2022 - nature.com
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

A conceptual framework for astrocyte function

C Murphy-Royal, SN Ching, T Papouin - Nature neuroscience, 2023 - nature.com
The participation of astrocytes in brain computation was hypothesized in 1992, coinciding
with the discovery that these cells display a form of intracellular Ca2+ signaling sensitive to …

Enteric glial biology, intercellular signalling and roles in gastrointestinal disease

L Seguella, BD Gulbransen - Nature reviews Gastroenterology & …, 2021 - nature.com
One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

Astrocyte function from information processing to cognition and cognitive impairment

M Santello, N Toni, A Volterra - Nature neuroscience, 2019 - nature.com
Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

Neural circuit-specialized astrocytes: transcriptomic, proteomic, morphological, and functional evidence

H Chai, B Diaz-Castro, E Shigetomi, E Monte… - Neuron, 2017 - cell.com
Astrocytes are ubiquitous in the brain and are widely held to be largely identical. However,
this view has not been fully tested, and the possibility that astrocytes are neural circuit …

Dopamine-evoked synaptic regulation in the nucleus accumbens requires astrocyte activity

M Corkrum, A Covelo, J Lines, L Bellocchio… - Neuron, 2020 - cell.com
Dopamine is involved in physiological processes like learning and memory, motor control
and reward, and pathological conditions such as Parkinson's disease and addiction. In …

Functional diversity of astrocytes in neural circuit regulation

LB Haim, DH Rowitch - Nature Reviews Neuroscience, 2017 - nature.com
Although it is well established that all brain regions contain various neuronal subtypes with
different functions, astrocytes have traditionally been thought to be homogenous. However …

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

I Farhy-Tselnicker, NJ Allen - Neural development, 2018 - Springer
In the mammalian cerebral cortex neurons are arranged in specific layers and form
connections both within the cortex and with other brain regions, thus forming a complex …

Questions and (some) answers on reactive astrocytes

C Escartin, O Guillemaud, M Carrillo‐de Sauvage - Glia, 2019 - Wiley Online Library
Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …

Diversity and specificity of astrocyte–neuron communication

CA Durkee, A Araque - Neuroscience, 2019 - Elsevier
Astrocytes are emerging as important players in synaptic function, and, consequently, on
brain function and animal behavior. According to the Tripartite Synapse concept, astrocytes …