Cytokines: key determinants of resistance or disease progression in visceral leishmaniasis: opportunities for novel diagnostics and immunotherapy

A Dayakar, S Chandrasekaran, SV Kuchipudi… - Frontiers in …, 2019 - frontiersin.org
Leishmaniasis is a parasitic disease of humans, highly prevalent in parts of the tropics,
subtropics, and southern Europe. The disease mainly occurs in three different clinical forms …

Regulation of immunity during visceral Leishmania infection

V Rodrigues, A Cordeiro-da-Silva, M Laforge… - Parasites & vectors, 2016 - Springer
Unicellular eukaryotes of the genus Leishmania are collectively responsible for a
heterogeneous group of diseases known as leishmaniasis. The visceral form of …

Mechanisms of immune evasion in leishmaniasis

G Gupta, S Oghumu, AR Satoskar - Advances in applied microbiology, 2013 - Elsevier
Diseases caused by Leishmania present a worldwide problem, and current therapeutic
approaches are unable to achieve a sterile cure. Leishmania is able to persist in host cells …

Role of cytokines in experimental and human visceral leishmaniasis

M Samant, U Sahu, SC Pandey… - Frontiers in cellular and …, 2021 - frontiersin.org
Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …

[HTML][HTML] Host immune response against leishmaniasis and parasite persistence strategies: A review and assessment of recent research

EK Elmahallawy, AAM Alkhaldi, AA Saleh - Biomedicine & …, 2021 - Elsevier
Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

The immunology of CD1-and MR1-restricted T cells

L Mori, M Lepore, G De Libero - Annual review of immunology, 2016 - annualreviews.org
CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …

The pathogenicity and virulence of Leishmania-interplay of virulence factors with host defenses

AK Gupta, S Das, M Kamran, SA Ejazi, N Ali - Virulence, 2022 - Taylor & Francis
Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the
genus Leishmania. Infection by different species of Leishmania results in various host …

Deception and Manipulation: The Arms of Leishmania, a Successful Parasite

P Cecílio, B Pérez-Cabezas, N Santarém… - Frontiers in …, 2014 - frontiersin.org
Leishmania spp. are intracellular parasitic protozoa responsible for a group of neglected
tropical diseases, endemic in 98 countries around the world, called leishmaniasis. These …

Innate immunity against Leishmania infections

P Gurung, TD Kanneganti - Cellular microbiology, 2015 - Wiley Online Library
Leishmaniasis is a major health problem that affects more than 300 million people
throughout the world. The morbidity associated with the disease causes serious economic …

Immunotherapy and immunochemotherapy in visceral leishmaniasis: promising treatments for this neglected disease

BM Roatt, RDO Aguiar-Soares, W Coura-Vital… - Frontiers in …, 2014 - frontiersin.org
Leishmaniasis has several clinical forms: self-healing or chronic cutaneous leishmaniasis or
post-kala-azar dermal leishmaniasis; mucosal leishmaniasis; visceral leishmaniasis (VL) …