The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …

The bromodomain is a highly conserved motif of 110 amino acids that is bundled into four
anti-parallel α-helices and found in proteins that interact with chromatin, such as …

Histone acetylation marks are written by histone acetyltransferases (HATs) and read by
bromodomains (BrDs), and less commonly by other protein modules. These proteins …

Small-molecule BET inhibitors interfere with the epigenetic interactions between acetylated
histones and the bromodomains of the BET family proteins, including BRD4, and they …

Brd4 is a double bromodomain-containing protein that binds preferentially to acetylated
chromatin. It belongs to the BET (bromodomains and extraterminal) family that includes …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

An unusual group of carcinomas, here termed nuclear protein in testis (NUT) midline
carcinomas (NMC), are characterized by translocations that involve NUT, a novel gene on …

The acetylation of histone lysine is central to providing the dynamic regulation of chromatin-
based gene transcription. The bromodomain (BRD), which is the conserved structural …

Latency is a state of cryptic viral infection associated with genomic persistence and highly
restricted gene expression. Its hallmark is reversibility: under appropriate circumstances …

Bromodomain and extra-terminal (BET) family member proteins (BRD2, BRD3, BRD4 and
BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac …