Despite tremendous progress in the past decade, the complex and heterogeneous nature of
cancer complicates efforts to identify new therapies and therapeutic combinations that …

Signal transduction and homeostasis are regulated by complex protein interactions in the
intracellular environment. Therefore, the transportation of impermeable macromolecules …

PBK (PDZ-binding kinase) is a protein-coding gene that encodes a serine/threonine protein
kinase associated with the dual-specific mitogen-activated protein kinase (MAPKK) family …

Adaptation to the shortage in free amino acids (AA) is mediated by 2 pathways, the
integrated stress response (ISR) and the mechanistic target of rapamycin (mTOR). In …

The systematic identification of tumour vulnerabilities through perturbational experiments on
cancer models, including genome editing and drug screens, is playing a crucial role in …

Bladder cancer (BC) represents a prevalent and formidable malignancy necessitating
innovative diagnostic and therapeutic strategies. Circular RNAs (circRNAs) have emerged …

The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for
cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein …

Unassembled and partially assembled subunits of multi-protein complexes have emerged
as major quality control clients, particularly under conditions of imbalanced gene expression …

Cancer genome alterations often lead to vulnerabilities that can be used to selectively target
cancer cells. Various inhibitors of such synthetic lethal targets have been approved by the …

Metformin is a regularly prescribed and low-cost generic medication. Metformin has been
proposed as a target for Dipeptidyl-peptidase 4 (DPP4) expression in various clinical …