Humans with salt-sensitive hypertension demonstrate increased morbidity, increased
mortality, and renal end-organ damage when compared with normotensive subjects or those …

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), represents a public health crisis of major …

Background Pathological cardiac hypertrophy is a result of afterload-increasing pathologies
including untreated hypertension and aortic stenosis. It features progressive adverse cardiac …

Th17 cells are a distinct component of the adaptive immune system that may strongly
enhance pathways leading to increased sodium reabsorption, elevated vascular tone and …

During development of the spontaneously hypertensive rat (SHR), several distinct but
closely related lines were generated. Most lines are resistant to hypertensive renal disease …

Hypertension (HTN) is a major contributor to kidney damage, leading to conditions such as
nephrosclerosis and hypertensive nephropathy, significant causes of chronic kidney disease …

Background: The present study in Sprague-Dawley rats determined the effects of a rapid rise
of renal perfusion pressure (RPP) upon the activation of mTOR (mechanistic target of …

Background Tie2, a functional angiopoietin receptor, is expressed in vascular endothelial
cells and plays an important role in angiogenesis and vascular stability. This study aimed to …

Although the molecular and functional responses related to renal compensatory hypertrophy
after unilateral nephrectomy (UNX) has been well described, many aspects of these events …

In the current study, we took advantage of the loss of protection from hypertension in
SSCD247−/− rats to characterize the pathological effects of renal T-cells in isolation from the …