Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …

Cross-linking mass spectrometry has become an established technology to provide
structural information on the topology and dynamics of protein complexes. Readily …

Elucidating protein–protein interaction (PPI) networks and their structural features within
cells is central to understanding fundamental biology and associations of cell phenotypes …

Chemical crosslinking coupled with mass spectrometry (CXMS) has emerged as a powerful
technique to obtain the dynamic conformations and interaction interfaces of protein …

Singlet oxygen (1O2) is the excited state of ground, triplet state, molecular oxygen (O2).
Photosensitized 1O2 has been extensively studied as one of the reactive oxygen species …

Bacteria have evolved toxins to outcompete other bacteria or to hijack host cell pathways.
One broad family of bacterial polymorphic toxins gathers multidomain proteins with a …

Biological systems have evolved to utilize proteins to accomplish nearly all functional roles
needed to sustain life. A majority of biological functions occur within the crowded …