Next-generation sequencing (NGS) is present in all fields of life science, which has greatly
promoted the development of basic research while being gradually applied in clinical …

Many viruses, including the clinically relevant RNA viruses HIV (human immunodeficiency
virus) and HCV (hepatitis C virus), exist in large populations and display high genetic …

The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for
productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 …

Viruses can create complex genetic populations within a host, and deep sequencing
technologies allow extensive sampling of these populations. Limitations of these …

To understand the high variability of the asymptomatic interval between primary human
immunodeficiency virus type 1 (HIV-1) infection and the development of AIDS, we studied …

Accurate identification of the transmitted virus and sequences evolving from it could be
instrumental in elucidating the transmission of human immunodeficiency virus type 1 (HIV-1) …

To investigate the extent to which drug resistance mutations are missed by standard
genotyping methods, we analyzed the same plasma samples from 26 patients with …

Antiretroviral therapy can reduce human immunodeficiency virus type 1 (HIV-1) viremia to
below the detection limit of ultrasensitive clinical assays (50 copies of HIV-1 RNA/ml) …

The HIV-1 epidemic in sub-Saharan Africa is driven largely by heterosexual transmission of
non-subtype B viruses, of which subtypes C and A are predominant. Previous studies of …

Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of the
donor quasispecies establishing the new infection. A critical, and as yet unresolved …