CRISPR-Cas: biology, mechanisms and relevance

F Hille, E Charpentier - … of the royal society B: biological …, 2016 - royalsocietypublishing.org
Prokaryotes have evolved several defence mechanisms to protect themselves from viral
predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their …

CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation

D Bhaya, M Davison, R Barrangou - Annual review of genetics, 2011 - annualreviews.org
Bacteria and archaea have evolved defense and regulatory mechanisms to cope with
various environmental stressors, including virus attack. This arsenal has been expanded by …

Bacterial strain typing in the genomic era

W Li, D Raoult, PE Fournier - FEMS microbiology reviews, 2009 - academic.oup.com
Bacterial strain typing, or identifying bacteria at the strain level, is particularly important for
diagnosis, treatment, and epidemiological surveillance of bacterial infections. This is …

The role of CRISPR-Cas systems in virulence of pathogenic bacteria

R Louwen, RHJ Staals, HP Endtz… - Microbiology and …, 2014 - Am Soc Microbiol
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) genes are present in many bacterial and archaeal genomes. Since the …

CRISPR: new horizons in phage resistance and strain identification

R Barrangou, P Horvath - Annual review of food science and …, 2012 - annualreviews.org
Bacteria have been widely used as starter cultures in the food industry, notably for the
fermentation of milk into dairy products such as cheese and yogurt. Lactic acid bacteria used …

CRISPRs: molecular signatures used for pathogen subtyping

N Shariat, EG Dudley - Applied and environmental microbiology, 2014 - Am Soc Microbiol
Rapid and accurate strain identification is paramount in the battle against microbial
outbreaks, and several subtyping approaches have been developed. One such method …

Phylum XXVI. Actinobacteria phyl. nov.

M Goodfellow - Bergey's manual® of systematic bacteriology, 2012 - Springer
This taxon is one of the major phyla in the domain Bacteria, as inferred from its branching
pattern in the 16S rRNA gene tree (Garrity and Holt, 2001; Ludwig and Klenk, 2005) and …

Evolution, epidemiology and diversity of Corynebacterium diphtheriae: new perspectives on an old foe

V Sangal, PA Hoskisson - Infection, Genetics and Evolution, 2016 - Elsevier
Diphtheria is a debilitating disease caused by toxigenic Corynebacterium diphtheriae strains
and has been effectively controlled by the toxoid vaccine, yet several recent outbreaks have …

Diphtheria in Europe: current problems and new challenges

K Zakikhany, A Efstratiou - Future microbiology, 2012 - Taylor & Francis
Diphtheria, caused by toxigenic strains of Corynebacterium diphtheriae, is an ancient
disease with high incidence and mortality that has always been characterized by epidemic …

Multilocus Sequence Typing Identifies Evidence for Recombination and Two Distinct Lineages of Corynebacterium diphtheriae

F Bolt, P Cassiday, ML Tondella… - Journal of Clinical …, 2010 - Am Soc Microbiol
We describe the development of a multilocus sequence typing (MLST) scheme for
Corynebacterium diphtheriae, the causative agent of the potentially fatal upper respiratory …