Abstract Novel coronavirus disease (COVID-19) has attracted much attention around the
world due to its rapid transmission among humans and relatively high mortality rate. Studies …

Coronaviruses (CoVs) infect humans and many animal species, and are associated with
respiratory, enteric, hepatic, and central nervous system diseases. The large size of the CoV …

Summary The biosafety level 3 (BSL-3) requirement to culture severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is a bottleneck for research. Here, we report a trans …

The multi-domain non-structural protein 3 of SARS-coronavirus is a component of the viral
replication/transcription complex (RTC). Among other domains, it contains three sequentially …

The emerging coronavirus disease 2019 (COVID-19) outbreak caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide, resulting …

Vaccines and antiviral agents are in urgent need to stop the COVID-19 pandemic. To
facilitate antiviral screening against SARS-CoV-2 without requirement for high biosafety …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, which is highly
pathogenic and classified as a biosafety level 3 (BSL-3) agent, has greatly threatened global …

The development of specific antiviral compounds to SARS-CoV-2 is an urgent task. One of
the obstacles for the antiviral development is the requirement of biocontainment because …

The COVID-19 pandemic continues to threaten healthcare systems worldwide due to the
limited access to vaccines, suboptimal treatment options, and the continuous emergence of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
pandemic worldwide. Vaccines and antiviral drugs are the most promising candidates for …