The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to
be studied, but one element has been unexplored: microproteins. Small open reading …

Hyperbaric oxygen treatment (HBOT)—the medical use of oxygen at environmental pressure
greater than one atmosphere absolute—is a very effective therapy for several approved …

Humanin (HN) is a small mitochondrial-derived cytoprotective polypeptide encoded by
mtDNA. HN exhibits protective effects in several cell types, including leukocytes, germ cells …

Astrocytes release functional mitochondria (Mt) that play regulatory and prosurvival functions
on entering adjacent cells. We recently demonstrated that these released Mts could enter …

Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …

Mitochondria are eukaryotic organelles known best for their roles in energy production and
metabolism. While often thought of as simply the 'powerhouse of the cell,'these organelles …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

Alzheimer's disease (AD) is a very disabling disease. Pathologically, it is characterized by
the presence of amyloid plaques and neurofibrillary tangles in the brain that results in …

Humanin (HN) belongs to a member of mitochondrial-derived peptides (MDPs) which are
encoded by mitochondrial genes. HN shares sequence homology with thirteen HN-like …

The renin–angiotensin system (RAS)—a classical blood pressure regulator—largely
contributes to healthy organ development and function. Besides, RAS activation promotes …