Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

The neuroscience community has witnessed a tremendous expansion of glia research. Glial
cells are now on center stage with leading roles in the development, maturation, and …

Depression is a common condition, but current treatments are only effective in a subset of
individuals. To identify new treatment targets, we integrated depression genome-wide …

Hundreds of human genes are associated with neurological diseases, but translation into
tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to …

Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …

The zebrafish telencephalon is composed of highly specialized subregions that regulate
complex behaviors such as learning, memory, and social interactions. The transcriptional …

Ribosome-associated quality control (RQC) pathways protect cells from toxicity caused by
incomplete protein products resulting from translation of damaged or problematic mRNAs …

Psychiatry, as a field, lacks objective markers for diagnosis, progression, treatment planning,
and prognosis, in part due to difficulties studying the brain in vivo, and diagnoses are based …

Pharmacology and toxicology are part of a much broader effort to understand the
relationship between chemistry and biology. While biomedicine has necessarily focused on …

CNNM/CorB proteins are a broadly conserved family of integral membrane proteins with
close to 90,000 protein sequences known. They are associated with Mg2+ transport but it is …