Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Host–microbiota maladaptation in colorectal cancer

A Janney, F Powrie, EH Mann - Nature, 2020 - nature.com
Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …

Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer …

F Chen, X Dai, CC Zhou, K Li, Y Zhang, XY Lou… - Gut, 2022 - gut.bmj.com
Objective To profile gut microbiome-associated metabolites in serum and investigate
whether these metabolites could distinguish individuals with colorectal cancer (CRC) or …

Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

E Piperni, LH Nguyen, P Manghi, H Kim, E Pasolli… - Cell, 2024 - cell.com
Diet impacts human health, influencing body adiposity and the risk of developing
cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

[HTML][HTML] Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

H Lin, Y Yu, L Zhu, N Lai, L Zhang, Y Guo, X Lin… - Redox Biology, 2023 - Elsevier
Hydrogen sulfide (H 2 S) is an important signaling molecule in colorectal cancer (CRC). It is
produced in the colon by the catalytic synthesis of the colonocytes' enzymatic systems and …

Role of Porphyromonas gingivalis in oral and orodigestive squamous cell carcinoma

RJ Lamont, ZR Fitzsimonds, H Wang… - Periodontology …, 2022 - Wiley Online Library
Oral and esophageal squamous cell carcinomas harbor a diverse microbiome that differs
compositionally from precancerous and healthy tissues. Though causality is yet to be …

Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men

W Ma, LH Nguyen, M Song, DD Wang, EA Franzosa… - Genome medicine, 2021 - Springer
Background A higher intake of dietary fiber is associated with a decreased risk of chronic
inflammatory diseases such as cardiovascular disease and inflammatory bowel disease …

Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 …

C Kong, X Yan, Y Zhu, H Zhu, Y Luo, P Liu… - Cancer Research, 2021 - AACR
Emerging research has revealed regulation of colorectal cancer metabolism by bacteria.
Fusobacterium nucleatum (Fn) plays a crucial role in the development of colorectal cancer …