Chordoma—current understanding and modern treatment paradigms

SM Barber, SS Sadrameli, JJ Lee, JS Fridley… - Journal of clinical …, 2021 - mdpi.com
Chordoma is a low-grade notochordal tumor of the skull base, mobile spine and sacrum
which behaves malignantly and confers a poor prognosis despite indolent growth patterns …

Management of locally recurrent chordoma of the mobile spine and sacrum: a systematic review

T Ailon, R Torabi, CG Fisher, LD Rhines, MJ Clarke… - Spine, 2016 - journals.lww.com
Study Design. Systematic review. Objective. To determine evidence-based guidelines for the
management of locally recurrent spinal chordoma. Summary of Background Data …

Biomimetic 3D-printed custom-made prosthesis for anterior column reconstruction in the thoracolumbar spine: a tailored option following en bloc resection for spinal …

M Girolami, S Boriani, S Bandiera… - European Spine …, 2018 - Springer
Purpose Various techniques for anterior column reconstruction have been described after
en bloc resection of spinal tumors. Limited evidence exists regarding one being superior to …

The role of radiotherapy for chordoma patients managed with surgery: analysis of the National Cancer Database

BL Dial, DL Kerr, AL Lazarides, AA Catanzano… - Spine, 2020 - journals.lww.com
Study Design. Retrospective review. Objective. To determine if adjuvant radiation therapy
(RT) improves overall survival (OS) following surgical resection of chordomas. Summary of …

Epidemiologic and survival trends in adult primary bone tumors of the spine

DL Kerr, BL Dial, AL Lazarides, AA Catanzano… - The Spine Journal, 2019 - Elsevier
BACKGROUND CONTEXT Malignant primary spinal tumors are rare making it difficult to
perform large studies comparing epidemiologic, survival, and treatment trends. We …

Immune checkpoint inhibitors have clinical activity in patients with recurrent chordoma

AJ Bishop, B Amini, H Lin, SM Raza… - Journal of …, 2022 - journals.lww.com
The aim of this study is to evaluate the outcomes and tolerance of immune checkpoint
inhibitors (ICIs) for patients with recurrent chordoma. We reviewed the records of 17 patients …

[HTML][HTML] Total en bloc resection of primary and metastatic spine tumors

EP Howell, T Williamson, I Karikari… - Annals of …, 2019 - ncbi.nlm.nih.gov
Primary and metastatic tumors of the spine represent a significant cause of patient morbidity,
and present a management challenge to treating providers. From a neurosurgical …

Current treatment strategy for newly diagnosed chordoma of the mobile spine and sacrum: results of an international survey

N Dea, CG Fisher, JJ Reynolds, JH Schwab… - … of Neurosurgery: Spine, 2018 - thejns.org
OBJECTIVE The purpose of this study was to investigate the spectrum of current treatment
protocols for managing newly diagnosed chordoma of the mobile spine and sacrum …

Development of machine learning algorithms for prediction of 5-year spinal chordoma survival

AV Karhade, Q Thio, P Ogink, J Kim… - World neurosurgery, 2018 - Elsevier
Background Chordomas are locally invasive slow-growing tumors that are difficult to study
because of the rarity of the tumors and the lack of significant volumes of patients with …

Surgical management of chordoma: a systematic review

L Denaro, A Berton, M Ciuffreda, M Loppini… - The journal of spinal …, 2020 - Taylor & Francis
Context: Chordomas are rare primary tumors of bone characterized by local aggressiveness
and poor prognosis. The surgical exeresis plays a critical role for their management …