Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies | New England Journal
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Objective: Prescription opioid abuse and dependence have escalated rapidly in the United
States over the past 20 years, leading to high rates of overdose deaths and a dramatic …

Importance Although clinical trials demonstrate the superior effectiveness of medication for
opioid use disorder (MOUD) compared with nonpharmacologic treatment, national data on …

Methods The Canadian Research Initiative in Substance Misuse (CRISM), a Canadian
Institutes of Health Research (CIHR)–funded research network composed of four regional …

Background Extended-release naltrexone (XR-NTX), an opioid antagonist, and sublingual
buprenorphine-naloxone (BUP-NX), a partial opioid agonist, are pharmacologically and …

Objectives. To estimate health outcomes of policies to mitigate the opioid epidemic.
Methods. We used dynamic compartmental modeling of US adults, in various pain, opioid …

Importance Buprenorphine treatment for opioid use disorder may be improved by sustained-
release formulations. Objective To determine whether treatment involving novel weekly and …

At least 2.3 million people in the US have an opioid use disorder, less than 40% of whom
receive evidence-based treatment. Buprenorphine used as part of medication-assisted …

Background Guidelines recommend long-term treatment for opioid use disorder with
buprenorphine; however, little is known about patients in long-term treatment. The aim of this …

Objective: Although counseling is a required part of office-based buprenorphine treatment of
opioid use disorders, the nature of what constitutes appropriate counseling is unclear and …