Biocatalytic reductive aminations with NAD (P) H-dependent enzymes: enzyme discovery, engineering and synthetic applications
Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …
reductive amination is one of the most efficient and atom economic methodologies for the …
Current Status of Amine Dehydrogenases: From Active Site Architecture to Diverse Applications Across a Broad Substrate Spectrum
Amine dehydrogenases (AmDHs) are NAD (P) H‐dependent oxidoreductases that catalyze
the reductive amination between carbonyl compounds and ammonia as the amine donor …
the reductive amination between carbonyl compounds and ammonia as the amine donor …
Reshaping substrate-binding pocket of leucine dehydrogenase for bidirectionally accessing structurally diverse substrates
T Wu, Y Wang, N Zhang, D Yin, Y Xu, Y Nie, X Mu - ACS Catalysis, 2022 - ACS Publications
Steric hindrance modification-based pocket reshaping is an effective approach for enzyme–
substrate acceptance evolution. However, previous studies were limited to using the …
substrate acceptance evolution. However, previous studies were limited to using the …
Biocatalytic synthesis of two furan-based amino compounds 2-acetyl-4-aminofuran and 3-acetylamino-5-(α-aminoethyl)-furan from chitin resources
C Wu, X Zhang, W Liu, C Wang, Q Jiang… - ACS Sustainable …, 2024 - ACS Publications
Chitin, as the second most abundant biomass in nature, possesses 7 wt% biologically fixed
nitrogen, and its direct valorization into valuable nitrogen (N)-containing chemicals is …
nitrogen, and its direct valorization into valuable nitrogen (N)-containing chemicals is …
Desymmetric reductive amination of 1, 3-cyclopentadiones to single stereoisomer of β-amino ketones with an all-carbon quaternary stereocenter by engineered amine …
T Lv, J Feng, X Chen, Y Luo, Q Wu, D Zhu, Y Ma - ACS Catalysis, 2023 - ACS Publications
Regio-and stereoselective reductive amination of diketones offers an attractive method to
access chiral β-amino ketones with multiple stereocenters which are unique scaffolds and …
access chiral β-amino ketones with multiple stereocenters which are unique scaffolds and …
Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis
Surfactant-enabled asymmetric ATA-catalyzed reductive aminations in aqueous buffered
media are described, representative of the enhanced levels of conversion made possible by …
media are described, representative of the enhanced levels of conversion made possible by …
Hydrophilicity‐based engineering of the active pocket of D‐amino acid oxidase leading to highly improved specificity toward D‐glufosinate
K Yang, B Huang, C Amanze, Z Yan, G Qiu… - Angewandte …, 2022 - Wiley Online Library
Due to its stringent stereospecificity, D‐amino acid oxidase (DAAO) has made it very easy to
synthesize L‐amino acids. However, the low activity of the wild‐type enzyme toward …
synthesize L‐amino acids. However, the low activity of the wild‐type enzyme toward …
Direct asymmetric reductive amination of alkyl (hetero) aryl ketones by an engineered amine dehydrogenase
W Kong, Y Liu, C Huang, L Zhou, J Gao… - Angewandte …, 2022 - Wiley Online Library
The direct asymmetric reductive amination of heteroaryl ketones has been a long‐standing
synthetic challenge. Here we report the engineering of an amine dehydrogenase (AmDH) …
synthetic challenge. Here we report the engineering of an amine dehydrogenase (AmDH) …
Shield Machine-like Substrate Walking Strategy-Based Pocket Engineering of F-Amine Dehydrogenase for Accessing Structurally Diverse Fused-Ring and Linked …
T Wu, Y Xu, Y Nie, X Mu - ACS Catalysis, 2024 - ACS Publications
Although amine dehydrogenases (AmDHs) are emerging as attractive biocatalysts for chiral
amine synthesis, their synthetic application in structurally diverse arylamines remains …
amine synthesis, their synthetic application in structurally diverse arylamines remains …
Improved synthesis of furfurylamine from a high titer of biomass-derived furfural by a thermostable triple mutant ω-transaminase in a three-component deep eutectic …
L Li, Q Li, J Di, Y He, C Ma - ACS Sustainable Chemistry & …, 2023 - ACS Publications
Furfurylamine (FLA) is widely utilized in manufacturing polymers, food additives, fibers, fuel
additives, flavors, and pharmaceuticals. Lignocellulose was tandemly transformed to …
additives, flavors, and pharmaceuticals. Lignocellulose was tandemly transformed to …