The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Drugs are typically small molecules that are generally classified as xenobiotics, which are
foreign to the human body. Several endogenous molecules, however, such as steroids and …

Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

Animal models are commonly used in the preclinical development of new drugs to predict
the metabolic behaviour of new compounds in humans. It is, however, important to realise …

The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …

Importance The antiepileptic drug phenytoin can cause cutaneous adverse reactions,
ranging from maculopapular exanthema to severe cutaneous adverse reactions, which …

We investigated the elimination routes for the 200 drugs that are sold most often by
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …

The discovery of six distinct polymorphisms in the genetic sequence encoding for the
cytochrome P450 2C9 (CYP2C9) protein has stimulated numerous investigations in an …

Background: The management of patients with acute nonvariceal upper gastrointestinal
bleeding has evolved substantially over the past 10 years amid a paucity of published …

Aims Several studies have demonstrated that the mutant* 2 allele of the CYP2C19 681G> A
loss-of-function polymorphism is associated with diminished metabolization of clopidogrel …