Calixarenes: Generalities and their role in improving the solubility, biocompatibility, stability, bioavailability, detection, and transport of biomolecules

ES Español, MM Villamil - Biomolecules, 2019 - mdpi.com
The properties and characteristics of calix [n] arenes are described, as well as their capacity
to form amphiphilic assemblies by means of the design of synthetic macrocycles with a …

Insights on the synthesis of n-heterocycles containing macrocycles and their complexion and biological properties

F Malek, T Harit, M Cherfi, B Kim - Molecules, 2022 - mdpi.com
Macrocyclic chemistry has been extensively developed over the past several decades. In
fact, the architecture of new macrocyclic models has undergone exponential growth to offer …

Synthesis, antimicrobial activity and in-silico docking of two macrocycles based on pyrazole-tetrazole subunit

M Cherfi, T Harit, MI Yahyaoui, A Riahi… - Journal of Molecular …, 2022 - Elsevier
The design of two new macrocycles bearing two pyrazole-tetrazole subunits and a lateral
arm is presented. These macrocycles and the intermediate compounds are characterized by …

New pyrazole-tetrazole hybrid compounds as potent α-amylase and non-enzymatic glycation inhibitors

A Oulous, NE Daoudi, T Harit, M Cherfi… - Bioorganic & Medicinal …, 2022 - Elsevier
The synthesis of eight novel pyrazole-tetrazole compounds are presented. Their structures
are identified by NMR and FTIR spectroscopy, mass spectrometry as well as elemental …

Synthesis of novel tetrazolic derivatives and evaluation of their antimicrobial activity

C Bourhou, H Benouda, R Bellaouchi… - Journal of Molecular …, 2023 - Elsevier
The microbial resistance to various anti-infective drugs remains a major worldwide health
problem. Therefore, the search for novel and effective antimicrobial agents is of paramount …

Study of the complexation of the stress hormone with (2-hydroxypropyl) α-, β-and γ-cyclodextrins in aqueous solution

M Maldonado, E Sanabria, CM Romero… - Journal of Molecular …, 2024 - Elsevier
In the present work, the interactions between hydrocortisone (11, 17, 21-trihydroxypregn-4-
ene-3, 20-dione, HC; stress hormone) and cyclodextrins were investigated. The …

[HTML][HTML] New family of tetrazole-pyrazole compounds: synthesis, characterization, antimicrobial activity and docking study

A Oulous, T Harit, MI Yahyaoui, A Asehraou… - Arabian Journal of …, 2023 - Elsevier
New pyrazole-tetrazole hybrid molecules were obtained via two synthetic pathways. The first
one is equimolar condensation of N-alkylated pyrazole with 1H-tetrazolic derivatives (yields …

Synthesis of new heterocyclic ligands and study of the catecholase activity of catalysts based on copper (II)

N Bouroumane, M El Boutaybi, M El Kodadi… - Reaction Kinetics …, 2023 - Springer
Four tridentate ligands L1-L4, namely N, N-bis ((3, 5-dimethyl-1H-pyrazol-1-yl) methyl)
pyridin-2-amine: L1, 5-chloro-N, N-bis ((3, 5-dimethyl-1H-pyrazol-1-yl) methyl) pyridin-2 …

Hybrid Pyrazole‐Tetrazole Derivatives with High α‐Amylase Inhibition Activity: Synthesis, Biological Evaluation and Docking Study

T Harit, M Cherfi, N Elhouda Daoudi, J Isaad… - …, 2022 - Wiley Online Library
The elaboration of some N‐alkylated pyrazole‐tetrazole derivatives is reported. The
structures of the newly ones are verified using NMR and FTIR spectroscopies, mass …

Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents

M Cherfi, I Dib, T Harit, A Ziyyat… - Drug Development …, 2021 - Wiley Online Library
The synthesis of new functionalized tetrazole–pyrazole compounds is reported. They were
fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of …