In vitro-in vivo correlation in nanocarriers: From protein corona to therapeutic implications

TG Agnihotri, A Alexander, M Agrawal… - Journal of Controlled …, 2023 - Elsevier
Understanding and establishing a link between the physicochemical characteristics of
nanoparticles (NPs) and their biological interactions poses to be a great challenge in the …

Targeted therapies against breast cancer: Clinical perspectives, obstacles and new opportunities

D Nagpal, R Verma, V Mittal, P Jeandet… - Journal of Drug Delivery …, 2023 - Elsevier
Breast cancer is a multifaceted, heterogeneous disease that manifests in the mammary
gland. According to the WHO, more than 2.3 million cases are diagnosed each year, making …

Nanomedicine ex machina: between model-informed development and artificial intelligence

M Villa Nova, TP Lin, S Shanehsazzadeh… - Frontiers in Digital …, 2022 - frontiersin.org
Today, a growing number of computational aids and simulations are shaping model-
informed drug development. Artificial intelligence, a family of self-learning algorithms, is only …

Comparison of compartmental and non-compartmental analysis to detect biopharmaceutical similarity of intravenous nanomaterial-based rifabutin formulations

N Osipova, A Budko, O Maksimenko, E Shipulo… - Pharmaceutics, 2023 - mdpi.com
Pharmacometric analysis is often used to quantify the differences and similarities between
formulation prototypes. In the regulatory framework, it plays a significant role in the …

Future Nanotechnology‐Based Strategies for Improved Management of Helicobacter pylori Infection

M Kamankesh, A Yadegar, A Llopis‐Lorente, C Liu… - Small, 2024 - Wiley Online Library
Helicobacter pylori (H. pylori) is a recalcitrant pathogen, which can cause gastric disorders.
During the past decades, polypharmacy‐based regimens, such as triple and quadruple …

[HTML][HTML] Putting square pegs in round holes: Why traditional pharmacokinetic principles cannot universally be applied to iron-carbohydrate complexes

AB Alston, R Digigow, B Flühmann… - European Journal of …, 2023 - Elsevier
Intravenous iron-carbohydrate complexes are nanomedicines that are commonly used to
treat iron deficiency and iron deficiency anemia of various etiologies. Many challenges …

A bio-predictive release assay for liposomal prednisolone phosphate

S Nagpal, J Png, L Kahouadji, MG Wacker - Journal of Controlled Release, 2024 - Elsevier
Predictive performance assays are crucial for the development and approval of
nanomedicines and their bioequivalent successors. At present, there are no established …

Simulate SubQ: the methods and the media

D Li, PY Chow, TP Lin, C Cheow, Z Li… - Journal of Pharmaceutical …, 2023 - Elsevier
For decades, there has been a growing interest in injectable subcutaneous formulations to
improve the absorption of drugs into the systemic circulation and to prolong their release …

Revisiting the in-vitro and in-vivo considerations for in-silico modelling of complex injectable drug products

A Dabke, S Ghosh, P Dabke, K Sawant… - Journal of Controlled …, 2023 - Elsevier
Complex injectable drug products (CIDPs) have often been developed to modulate the
pharmacokinetics along with efficacy for therapeutic agents used for remediation of chronic …

Modeling the Drug delivery Lifecycle of PLG Nanoparticles Using Intravital Microscopy

Z Li, T Kovshova, J Malinovskaya, M Valikhov… - Small, 2023 - Wiley Online Library
Abstract Polylactide‐co‐glycolide (PLG) nanoparticles hold immense promise for cancer
therapy due to their enhanced efficacy and biodegradable matrix structure. Understanding …