The effect of metal ions (Fe, Co, Ni, and Cu) on the molecular-structural, protein binding, and cytotoxic properties of metal pyridoxal-thiosemicarbazone complexes

V Jevtovic, AK Alshamari, D Milenković… - International journal of …, 2023 - mdpi.com
Thiosemicarbazones and their transition metal complexes are biologically active
compounds and anticancer agents with versatile structural properties. In this contribution …

Michael addition-driven synthesis of cytotoxic palladium (ii) complexes from chromone thiosemicarbazones: investigation of anticancer activity through in vitro and in …

J Haribabu, N Balakrishnan, S Swaminathan… - New Journal of …, 2023 - pubs.rsc.org
Three Pd (II) complexes (1–3) containing tridentate chromone-based thiosemicarbazones
(SVSHL1–3) have been investigated as potential anticancer agents. The complexes of the …

Crystal Structure, Theoretical Analysis, and Protein/DNA Binding Activity of Iron(III) Complex Containing Differently Protonated Pyridoxal–S-Methyl …

V Jevtovic, L Golubović, B Alshammari… - International journal of …, 2024 - mdpi.com
Pyridoxal–S-methyl-isothiosemicarbazone (PLITSC) is a member of an important group of
ligands characterized by different complexation modes to various transition metals. In this …

Syntheses and coordination chemistry of thiosemicarbazone-based titanium complexes

K Schwitalla, M Claußen, M Schmidtmann… - New Journal of …, 2024 - pubs.rsc.org
Two routes leading to thiosemicarbazone-based complexes are reported with the view of
developing ionic titanium complexes as cytotoxic metallodrugs. The reaction of bis (π-η5: σ …

Proving the Antimicrobial Therapeutic Activity on a New Copper–Thiosemicarbazone Complex

D Fabra, G Amariei, D Ruiz-Camino… - Molecular …, 2024 - ACS Publications
The misuse and overdose of antimicrobial medicines are fostering the emergence of novel
drug-resistant pathogens, providing negative repercussions not only on the global …

[HTML][HTML] A select thiosemicarbazone copper (II) complex induces apoptosis in gastric cancer and targets cancer stem cells reducing pluripotency markers

D Fabra, J Melones-Herrero… - European Journal of …, 2024 - Elsevier
Copper (II)-based complexes are promising candidates as anti-cancer agents due to their
ability to target cancer cells. Here we describe the synthesis and characterization of two …

Synthesis, structural characterisation, and anticancer potential of mono and dinuclear Pd (II) complexes of N-(2-pyridyl) thiourea

SK Pandey, S Kumar, S Singh, AK Patel… - Dalton …, 2025 - pubs.rsc.org
Cancer is a prominent global cause of mortality. Palladium complexes have the potential to
serve as effective anticancer and pharmacological agents, offering a viable alternative to …

Structure-bioactivity relationship study on anticancer Pd and Pt complexes with aliphatic glycine derivative ligands

Z Hosseini-Hashemi, ME Moghadam, B Notash… - … Acta Part A: Molecular …, 2024 - Elsevier
To investigate the structure and bioactivity relationship, six Pd (II)/Pt (II) complexes with N-
isobutylglycine (L 1) and cyclohexylglycine (L 2) as N^ O amino acid bidentate ligands, 1 …

[HTML][HTML] Pd (II)/1, 10-phenanthroline complexes bearing arene ligands: On the role of N-vs O-coordination to tune their cellular activity and binding ability towards DNA …

F Binacchi, D Cirri, E Bimbi, N Busto, A Pratesi… - Journal of Inorganic …, 2025 - Elsevier
Three Pd (II)-based complexes of 1, 10-phenanthroline and N-or O-coordinating ligands
have been synthesised and tested with different relevant biosubstrates like double-stranded …

Dithiobiureas Palladium (II) complexes' studies: From their synthesis to their biological action

JM Herrero, D Fabra, AI Matesanz, C Hernández… - Journal of Inorganic …, 2023 - Elsevier
Dithiobiureas coordination chemistry towards palladium (II) ions and their possible
application is presented and discussed. 1, 6-(4-Methoxyphenyl)-2, 5-dithiobiurea and 1, 6-(4 …