M Koch - Progress in neurobiology, 1999 - Elsevier
Startle is a fast response to sudden, intense stimuli and probably protects the organism from injury by a predator or by a blow. The acoustic startle response (ASR) of mammals is …
Rationale: Sensorimotor gating of the startle reflex can be assessed across species, using similar stimuli to elicit similar responses. Prepulse inhibition (PPI), a measure of …
M Koch, HU Schnitzler - Behavioural brain research, 1997 - Elsevier
This review describes the neuronal mechanisms underlying the mediation and modulation of the acoustic startle response (ASR) in rats. The combination of anatomical, physiological …
Certain animal models can greatly enhance our understanding of the neurobiology of schizophrenia and can be used to predict the antipsychotic activity of compounds. Prepulse …
TM Tzschentke - Progress in neurobiology, 2001 - Elsevier
The prefrontal cortex (PFC) has long been known to be involved in the mediation of complex behavioral responses. Considerable research efforts are directed towards refining the …
PJ Lang, RF Simons, M Balaban, R Simons - 2013 - api.taylorfrancis.com
Orienting is the gateway to attention, the first step in processing stimulus information. This volume examines these initial stages of information intake, focusing on the sensory and …
Asperger's syndrome (an autistic disorder) is characterized by stereotyped and obsessional behaviours, and pervasive abnormalities in socio‐emotional and communicative behaviour …
DL Braff, NR Swerdlow… - American Journal of …, 1999 - Am Psychiatric Assoc
OBJECTIVE: Information processing, inhibitory, and gating deficits in human and animal model studies of schizophrenia are demonstrated by using prepulse inhibition of the startle …
NR Swerdlow, DL Braff, MA Geyer - Behavioural pharmacology, 2000 - journals.lww.com
Sensorimotor gating of the startle reflex can be studied in humans and laboratory animals using measures of prepulse inhibition (PPI) of the startle reflex. PPI is reduced in patients …