Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Amino acid dysregulation has emerged as an important driver of disease progression in
various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate …

Drug safety initiatives have endorsed human iPSC-derived cardiomyocytes (hiPSC-CMs) as
an in vitro model for predicting drug-induced cardiac arrhythmia. However, the extent to …

Serine has functions that are involved in metabolic homeostasis and health in pathological
or stressful situations. Notably, the de novo serine synthesis pathway (SSP) plays a vital role …

Precision medicine strives for highly individualized treatments for disease under the notion
that each individual's unique genetic makeup and environmental exposures imprints upon …

Metabolic homeostasis is maintained by redundant pathways to ensure adequate nutrient
supply during fasting and other stresses. These pathways are regulated locally in tissues …

Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-
communicable disease deaths. Glycolysis is a conserved and rigorous biological process …

Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and
pharmaceutical research by providing tissue-specific human cells that retain patients' …

Cardiovascular diseases persist as a global health challenge that requires methodological
innovation for effective drug development. Conventional pipelines relying on animal models …

Background Pulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and
variable response to therapy. The metabolome has been implicated in the pathogenesis of …