Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

BACKGROUND Non-classic congenital hyperplasia (NCAH) due to 21-hydroxylase
deficiency is a common autosomal recessive disorder characterized by androgen excess …

This paper represents an international collaboration of paediatric endocrine and other
societies (listed in the Appendix) under the International Consortium of Paediatric …

CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …

Context Adrenarche refers to the rise of dehydroepiandrosterone sulfate (DHEA-S)
associated with the development of a functional adrenal zona reticularis. Clinical features of …

The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been
written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has …

CYP17A1 is an enzyme that plays a major role in steroidogenesis and is critically involved in
the biosynthesis of steroid hormones. Therefore, it remains an attractive target in several …

The testis is an important male reproductive organ, which ensures reproductive function via
the secretion of testosterone and the generation of spermatozoa. Testis development begins …

In a healthy female reproductive system, a subtle hormonal and metabolic dance leads to
repetitive cyclic changes in the ovaries and uterus, which make an effective ovulation and …

The discovery of “oestrus-producing” hormones was a major research breakthrough in
biochemistry and pharmacology during the early part of the 20th century. The elucidation of …