[HTML][HTML] Natural killer cell homing and trafficking in tissues and tumors: from biology to application

GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

[HTML][HTML] Aging of the immune system: focus on natural killer cells phenotype and functions

A Brauning, M Rae, G Zhu, E Fulton, TD Admasu… - Cells, 2022 - mdpi.com
Aging is the greatest risk factor for nearly all major chronic diseases, including
cardiovascular diseases, cancer, Alzheimer's and other neurodegenerative diseases of …

Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry

A Horowitz, DM Strauss-Albee, M Leipold… - Science translational …, 2013 - science.org
Natural killer (NK) cells play critical roles in immune defense and reproduction, yet remain
the most poorly understood major lymphocyte population. Because their activation is …

[HTML][HTML] Uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice

LM Gaynor, F Colucci - Frontiers in immunology, 2017 - frontiersin.org
Our understanding of development and function of natural killer (NK) cells has progressed
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …

Natural killer cell education and the response to infection and cancer therapy: stay tuned

JE Boudreau, KC Hsu - Trends in immunology, 2018 - cell.com
The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …

Natural killer cells unleashed: checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

ZB Davis, DA Vallera, JS Miller, M Felices - Seminars in Immunology, 2017 - Elsevier
Natural killer (NK) cells have long been known to mediate anti-tumor responses without prior
sensitization or recognition of specific tumor antigens. However, the tumor microenvironment …

Newtonian cell interactions shape natural killer cell education

JP Goodridge, B Önfelt, KJ Malmberg - Immunological reviews, 2015 - Wiley Online Library
Newton's third law of motion states that for every action on a physical object there is an
equal and opposite reaction. The dynamic change in functional potential of natural killer …

[HTML][HTML] Mouse models for immune checkpoint blockade therapeutic research in oral cancer

WC Chiu, DL Ou, CT Tan - International Journal of Molecular Sciences, 2022 - mdpi.com
The most prevalent oral cancer globally is oral squamous cell carcinoma (OSCC). The
invasion of adjacent bones and the metastasis to regional lymph nodes often lead to poor …

[HTML][HTML] Humanized mouse models for the advancement of innate lymphoid cell-based cancer immunotherapies

NB Horowitz, I Mohammad, UY Moreno-Nieves… - Frontiers in …, 2021 - frontiersin.org
Innate lymphoid cells (ILCs) are a branch of the immune system that consists of diverse
circulating and tissue-resident cells, which carry out functions including homeostasis and …

Dynamic regulation of NK cell responsiveness

N Kadri, AK Wagner, S Ganesan, K Kärre… - Natural Killer …, 2016 - Springer
Natural killer (NK) cells deliver cytotoxic granules and immunomodulatory cytokines in
response to transformed and virally infected cells. NK cell functions are under the control of …