Tumour-specific antigens have been an area of interest in cancer therapy since their
discovery in the middle of the 20th century. In the era of immune-based cancer therapeutics …

Tumor cells frequently exhibit widespread epigenetic aberrations that significantly alter the
repertoire of expressed proteins. In particular, it has been known for nearly 25 years that …

Testicular germ cell tumours (TGCTs) are the most common cancer in young men. Here we
perform whole-exome sequencing (WES) of 42 TGCTs to comprehensively study the …

Genome-wide association studies (GWAS) have transformed understanding of susceptibility
to testicular germ cell tumors (TGCTs), but much of the heritability remains unexplained …

Tumors of nearly every origin activate the expression of genes normally restricted to
gametogenic cells. These genes encode proteins termed cancer/testis (CT) antigens, since …

We conducted a meta-analysis to identify new susceptibility loci for testicular germ cell tumor
(TGCT). In the discovery phase, we analyzed 931 affected individuals and 1,975 controls …

Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable
for its high familial risks,. So far, six loci associated with TGCT have been reported,,,,. From …

Polo-like kinase (Plk) 1 executes several essential functions to promote cell division. These
functions range from centrosome maturation in late G2 phase to the regulation of …

The incidence and mortality rate of breast cancer increases yearly by an average of 1.44%
and 0.23%, respectively. Till 2021, there were 7.8 million women who had been diagnosed …

Over the past decade, our understanding of the mechanisms by which pseudokinases,
which comprise∼ 10% of the human and mouse kinomes, mediate signal transduction has …