Thermostability is an essential requirement of enzymes in the industrial processes to
catalyze the reactions at high temperatures; thus, enzyme engineering through directed …

Tryptophan is an aromatic amino acid with unique physico-chemical properties. It is often
encountered in membrane proteins, especially at the level of the water/bilayer interface. It …

Antiviral peptide (AVP) is a kind of antimicrobial peptide (AMP) that has the potential ability
to fight against virus infection. Machine learning-based prediction with a computational …

Over the past decade, the vast amount of information generated through structural and
biophysical studies of GPCRs has provided unprecedented mechanistic insight into the …

Amphipathic copolymers such as poly (styrene-maleic acid)(SMA) are promising tools for the
facile extraction of membrane proteins (MPs) into native nanodiscs. Here, we designed and …

Biomimetic cubic phases can be used for protein encapsulation in a variety of applications
such as biosensors and drug delivery. Cubic phases with a high concentration of cholesterol …

Despite advances in membrane protein (MP) structural biology and a growing interest in
their applications, these proteins remain challenging to study. Progress has been hindered …

In solution, the charge of a protein is intricately linked to its stability, but electrospray
ionization distorts this connection, potentially limiting the ability of native mass spectrometry …

EpCAM has long been known as a cell surface protein highly expressed in carcinomas. It
has since become one of the key cancer biomarkers. Despite its high fame, its actual role in …

Mutual positioning and non-covalent interactions in anion–aromatic motifs are crucial for
functional performance of biological systems. In this context, regular, comprehensive Protein …