Chromosomal instability (CIN) is a pervasive feature of human cancers involved in tumor
initiation and progression and which is found elevated in metastatic stages. CIN can provide …

Highlights•Epigenetic transcriptional regulation allows for maintenance of stable expression
states.•Epigenetic regulation requires DNA methylation, lncRNAs or histone modifications.• …

Abstract HOTAIR is a 2.2-kb long noncoding RNA (lncRNA) whose dysregulation has been
linked to oncogenesis, defects in pattern formation during early development, and …

Men of African descent have the highest prostate cancer incidence and mortality rates, yet
the genetic basis of prostate cancer in African men has been understudied. We used …

Centromeres are critical structures involved in chromosome segregation, maintaining
genomic stability, and facilitating the accurate transmission of genetic information. They are …

In this review, we provide a general overview of the current panorama of mining strategies
for multi-omics data to investigate lncRNAs with an actual or potential role as biological …

Centromeres play a crucial role in DNA segregation by mediating the cohesion and
separation of sister chromatids during cell division. Centromere dysfunction, breakage or …

Aging is an inexorable event occurring universally for all organisms characterized by the
progressive loss of cell function. However, less is known about the key events occurring …

Long non-coding RNAs (lncRNAs) are significant contributors in maintaining genomic
integrity through epigenetic regulation. LncRNAs can interact with chromatin-modifying …

Background: The prostate cancer subtype defined by the presence of TMPRSS2: ERG has
been shown to be molecularly and epidemiologically distinct. However, few studies have …