Background Single-cell genomics techniques are revolutionizing our ability to characterize
complex tissues. By contrast, the techniques used to analyze renal biopsy specimens have …

Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

The molecular mechanisms operating in human organ transplant rejection are best inferred
from the mRNAs expressed in biopsies because the corresponding proteins often have low …

Progress in renal transplantation requires improved understanding and assessment of
rejection and injury. Study of the relationship between gene expression and clinical …

Diagnosis of renal transplant rejection is dependent on interpretation of renal allograft
biopsies. The Banff Classification of Allograft Pathology, which was developed as a …

Inflammation within areas of interstitial fibrosis and tubular atrophy (i-IFTA) is associated with
adverse outcomes in kidney transplantation. We evaluated i-IFTA in 429 indication-and …

Noninvasive biomarkers are needed to monitor stable patients after kidney transplant (KT),
because subclinical acute rejection (subAR), currently detectable only with surveillance …

New biomarkers of early and late graft dysfunction are needed in renal transplant to improve
management of complications and prolong graft survival. A wide range of potential …

Donor-recipient (DR) mismatches outside of human leukocyte antigens (HLAs) contribute to
kidney allograft loss, but the mechanisms remain unclear, specifically for intronic …