Methods to enhance the metabolic stability of peptide-based PET radiopharmaceuticals

BJ Evans, AT King, A Katsifis, L Matesic, JF Jamie - Molecules, 2020 - mdpi.com
The high affinity and specificity of peptides towards biological targets, in addition to their
favorable pharmacological properties, has encouraged the development of many peptide …

Bifunctional gallium-68 chelators: Past, present, and future

P Spang, C Herrmann, F Roesch - Seminars in nuclear medicine, 2016 - Elsevier
This article reviews the development of bifunctional chelates for synthesising 68 Ga
radiopharmaceuticals. It structures the chelates into groups of macrocycles …

Radiolabeled bombesin analogs

R Mansi, BA Nock, SU Dalm, MB Busstra… - Cancers, 2021 - mdpi.com
Simple Summary Recent medical advancements have strived for a personalized medicine
approach to patients, aimed at optimizing therapy outcomes with minimum toxicity. In this …

SPAAC-NAD-seq, a sensitive and accurate method to profile NAD+-capped transcripts

H Hu, N Flynn, H Zhang, C You… - Proceedings of the …, 2021 - National Acad Sciences
Nicotinamide adenine diphosphate (NAD+) is a novel messenger RNA 5′ cap in
Escherichia coli, yeast, mammals, and Arabidopsis. Transcriptome-wide identification of …

Trifunctional PSMA-targeting constructs for prostate cancer with unprecedented localization to LNCaP tumors

J Kelly, A Amor-Coarasa, S Ponnala… - European Journal of …, 2018 - Springer
Purpose Treatment of late-stage prostate cancer by targeted radiotherapeutics such as 131 I-
MIP-1095 and 177 Lu-PSMA-617 has shown encouraging early results. Lu-177 is preferred …

Phase I Trial of [99mTc]Tc-maSSS-PEG2-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR …

V Chernov, A Rybina, R Zelchan, A Medvedeva… - Cancers, 2023 - mdpi.com
Simple Summary Prostate and breast cancers are the most common malignancies. Accurate
diagnosis and staging of diseases are important for the prognosis and determination of …

Towards the magic radioactive bullet: improving targeted radionuclide therapy by reducing the renal retention of radioligands

KE de Roode, L Joosten, M Behe - Pharmaceuticals, 2024 - mdpi.com
Targeted radionuclide therapy (TRT) is an emerging field and has the potential to become a
major pillar in effective cancer treatment. Several pharmaceuticals are already in routine use …

The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody

A Guillou, DF Earley, S Klingler, E Nisli… - Bioconjugate …, 2021 - ACS Publications
Most experimental work in the space of bioconjugation chemistry focuses on using new
methods to construct covalent bonds between a cargo molecule and a protein of interest …

Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer

B Mitran, Z Varasteh, A Abouzayed, SS Rinne… - Cancers, 2019 - mdpi.com
Simultaneous targeting of the prostate-specific membrane antigen (PSMA) and gastrin-
releasing peptide receptor (GRPR) could improve the diagnostic accuracy in prostate cancer …

[HTML][HTML] 18F-AmBF3-MJ9: A novel radiofluorinated bombesin derivative for prostate cancer imaging

M Pourghiasian, Z Liu, J Pan, Z Zhang, N Colpo… - Bioorganic & Medicinal …, 2015 - Elsevier
A novel radiofluorinated derivative of bombesin, 18 F-AmBF 3-MJ9, was synthesized and
evaluated for its potential to image prostate cancer by targeting the gastrin releasing peptide …