Graft-versus-leukemia effects of transplantation and donor lymphocytes

HJ Kolb - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
Allogeneic transplantation of hematopoietic cells is an effective treatment of leukemia, even
in advanced stages. Allogeneic lymphocytes produce a strong graft-versus-leukemia (GVL) …

Graft-versus-leukemia reactions in allogeneic chimeras

HJ Kolb, C Schmid, AJ Barrett, DJ Schendel - Blood, 2004 - ashpublications.org
There is a strong graft-versus-leukemia (GVL) effect of allogeneic stem cell transplantation
(SCT) due to elimination of tumor cells by alloimmune effector lymphocytes. When leukemia …

PD-1 blockade for relapsed lymphoma post–allogeneic hematopoietic cell transplant: high response rate but frequent GVHD

BM Haverkos, D Abbott, M Hamadani… - Blood, The Journal …, 2017 - ashpublications.org
Given the limited treatment options for relapsed lymphoma post–allogeneic hematopoietic
cell transplantation (post–allo-HCT) and the success of programmed death 1 (PD-1) …

[HTML][HTML] Survival of patients with acute myeloid leukemia relapsing after allogeneic hematopoietic cell transplantation: a center for international blood and marrow …

N Bejanyan, DJ Weisdorf, BR Logan, HL Wang… - Biology of Blood and …, 2015 - Elsevier
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation
(alloHCT) remains a major therapeutic challenge. We studied outcomes of 1788 AML …

Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: results of the RELAZA trial

U Platzbecker, M Wermke, J Radke, U Oelschlaegel… - Leukemia, 2012 - nature.com
This study evaluated azacitidine as treatment of minimal residual disease (MRD) determined
by a sensitive donor chimerism analysis of CD34+ blood cells to pre-empt relapse in …

Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: a …

C Schmid, M Labopin, A Nagler… - Journal of clinical …, 2007 - ascopubs.org
Purpose To evaluate the role of donor lymphocyte infusion (DLI) in the treatment of relapsed
acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation …

Treatment, risk factors, and outcome of adults with relapsed AML after reduced intensity conditioning for allogeneic stem cell transplantation

C Schmid, M Labopin, A Nagler… - Blood, The Journal …, 2012 - ashpublications.org
Because information on management and outcome of AML relapse after allogeneic
hematopoietic stem cell transplantation (HSCT) with reduced intensity conditioning (RIC) is …

Hematopoiesis-restricted minor histocompatibility antigens HA-1-or HA-2-specific T cells can induce complete remissions of relapsed leukemia

WAE Marijt, MHM Heemskerk… - Proceedings of the …, 2003 - National Acad Sciences
Donor lymphocyte infusion (DLI) into patients with a relapse of their leukemia or multiple
myeloma after allogeneic stem cell transplantation (alloSCT) has been shown to be a …

Memory-like natural killer cells for cancer immunotherapy

M Gang, P Wong, MM Berrien-Elliott… - Seminars in hematology, 2020 - Elsevier
Natural killer (NK) cells are cytotoxic innate lymphoid cells that protect the host from infection
and mediate anti-tumor responses. Classically considered part of the innate immune system …

Relapse after allogeneic stem cell transplantation

AJ Barrett, M Battiwalla - Expert review of hematology, 2010 - Taylor & Francis
Since allogeneic stem cell transplantation (SCT) represents an intensive curative treatment
for high-risk malignancies, its failure to prevent relapse leaves few options for successful …