MASLD: a systemic metabolic disorder with cardiovascular and malignant complications

G Targher, CD Byrne, H Tilg - Gut, 2024 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic
liver disease globally and is currently estimated to affect up to 38% of the global adult …

NAFLD and NASH: etiology, targets and emerging therapies

S Wei, L Wang, PC Evans, S Xu - Drug Discovery Today, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) pose a
significant threat to human health and cause a tremendous socioeconomic burden …

Quantitative imaging reveals steatosis and fibro-inflammation in multiple organs in people with type 2 diabetes: a real-world study.

C Diamond, M Pansini, A Hamid, N Eichert… - Diabetes, 2024 - Am Diabetes Assoc
We aimed to determine the extent of multi-organ fat accumulation and fibro-inflammation in
individuals living with type 2 diabetes. We deeply phenotyped individuals with type 2 …

Liver steatosis linked to type 2 diabetes outcomes

N Bhala - bmj, 2024 - bmj.com
Although non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis are
increasingly recognised globally, 1 these terms were updated in June 2023 by an …

[HTML][HTML] Prediction of early recovery of graft function after living donor liver transplantation in children

B Tan, C Yang, J Hu, H Xing, M Zhang - Scientific Reports, 2024 - nature.com
For end-stage liver disease in children, living donor liver transplantation (LDLT) is often the
important standard curative treatment. However, there is a lack of research on early recovery …

[HTML][HTML] Liver fibrosis assessed via non-invasive tests is associated with incident heart failure in a general population cohort

TJ Hydes, OJ Kennedy, K Glyn-Owen… - Clinical …, 2024 - Elsevier
Background & Aims The aim of this study was to determine whether liver fibrosis is
associated with heart failure in a general population cohort, and if genetic polymorphisms …

[HTML][HTML] Effect of essential phospholipids on hepatic steatosis in metabolic dysfunction-associated steatotic liver disease associated with type 2 diabetes mellitus and …

N Stefan, M Hartleb, B Popovic, R Varona - Trials, 2024 - Springer
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a
predominant chronic liver condition globally and is strongly associated with obesity …

Associations of life's essential 8 with MAFLD and liver fibrosis among US adults: a nationwide cross-section study

D Liang, J Zhang, L Li, Y Li, L Xu, H Wu - Frontiers in Nutrition, 2024 - frontiersin.org
Background Life's essential'8 (LE8) is a newly updated cardiovascular health (CVH) metrics
from the American Heart Association, with close relevance to metabolism. Our objective is to …

[HTML][HTML] Elevated FIB-4 Is Associated with Higher Rates of Cardiovascular Disease and Extrahepatic Cancer History in Patients with Type 2 Diabetes Mellitus

DS Karagiannakis, K Stefanaki, F Petrea, P Zacharaki… - Biomedicines, 2024 - mdpi.com
Background: Type 2 diabetes mellitus (T2DM) is often complicated by steatotic liver disease,
cardiovascular disease (CVD), and extrahepatic cancer. We investigated whether FIB-4, an …

Reassessing the causal relationship between liver diseases and cardiovascular outcomes

X Xiang, Y Wei, K Zhao - Journal of Hepatology, 2024 - journal-of-hepatology.eu
To the Editor, We read with great interest the study by Roca-Fernandez et al. which revealed
the Liver disease activity (measured by iron corrected T1-mapping (cT1)) was independently …