Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …

In this review, recent examples featuring C–H functionalization in the synthesis of complex
natural products are discussed. A focus is given to the way in which C–H functionalization …

Conspectus The functionalization of unactivated carbon–hydrogen bonds is a transformative
strategy for the rapid construction of molecular complexity given the ubiquitous presence of …

This Review summarizes the advancements in Pd-catalyzed C (sp3)–H activation via
various redox manifolds, including Pd (0)/Pd (II), Pd (II)/Pd (IV), and Pd (II)/Pd (0). While few …

The oxidation of unactivated C–H bonds has emerged as an effective tactic in natural
product synthesis and has altered how chemists approach the synthesis of complex …

Methods that enable the practical and selective functionalization of traditionally unreactive
aliphatic C–H bonds have synthetic applications in fields ranging from drug discovery to …

The synergistic combination of NiH-catalyzed alkene isomerization with nickel-catalyzed
cross-coupling has yielded a general protocol for the synthesis of a wide range of …

Methylation is a well‐known structural modification in organic and medicinal chemistry. This
review summarizes recent advances in methylation by categorizing specific methylation …

C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …