Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

Sudden cardiac death (SCD) from arrhythmias is a leading cause of mortality. For patients at
high SCD risk, prophylactic insertion of implantable cardioverter defibrillators (ICDs) reduces …

Ventricular tachycardia (VT), which can lead to sudden cardiac death, occurs frequently in
patients with myocardial infarction. Catheter-based radio-frequency ablation of cardiac …

The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …

Early prediction of cardiotoxicity is critical for drug development. Current animal models
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

In this paper, we present an open-source multi-resolution and multi-physics library,
SPHinXsys, which is released under the Apache License (2.0). Along with the source code …