Process simulation using mathematical modeling tools is becoming more common in the
pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can …

Coating of tablets is a common unit operation in the pharmaceutical industry. In most cases,
the final product must meet strict quality requirements; to meet them, a detailed …

Scale up of pan coating process is of high importance to the pharmaceutical and food
industry. The number of process variables and their interdependence in a pan coating …

The ability to coat particles with a uniform film of a desired thickness is a key requirement in
many industries such as pharmaceuticals, food processing and chemical manufacture …

Spray coating of tablets is an important unit operation in the pharmaceutical industry and is
mainly used for modified release, enteric protection, better appearance and brand …

The objective of this study was to prepare and evaluate some physiochemical and
biopharmaceutical properties of bitter taste masking microparticles containing azithromycin …

A multiscale model by coupling computational fluid dynamics (CFD) with a discrete element
model (DEM) and discrete droplet model (DDM) is developed to simulate a lab-scale …

Process understanding for designing, optimizing and scaling of pharmaceutical unit
operations is fundamentally important to address concerns of high risks, monumental costs …

In this paper, the coating process of tablets is investigated based on the discrete element
method (DEM), where tablets are modeled by super-ellipsoids and the spray droplets are …

Extended release (ER) of water-soluble drugs from hydroxypropylmethylcellulose (HPMC)
matrix mini-tablets (mini-matrices) is difficult to achieve due to the large surface area to …