Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Immune checkpoint inhibitors and related molecules can achieve tumour regression, and
even prolonged survival, for a subset of cancer patients with an otherwise dire prognosis …

Abstract Claudin18. 2 (CLDN18. 2) is a tight junction protein that is overexpressed in a
variety of solid tumors such as gastrointestinal cancer and oesophageal cancer. It has been …

Diagnostic molecular images, obtained by positron emission tomography (PET), have
successfully functioned as sensitive tools for detecting and monitoring the treatment of …

The combination of targeting ligands and fluorescent dyes is a powerful strategy to observe
cell types and tissues of interest. Conjugates of peptides, proteins, and, in particular …

Positron emission tomography (PET) and single-photon emission computed tomography
(SPECT) are molecular imaging strategies that typically use radioactively labeled ligands to …

Despite the remarkable clinical successes of immune checkpoint inhibitors (ICIs) in various
advanced cancers, response is still limited to a subset of patients that generally exhibit …

Rationale: The overwhelming majority of radioimmunoconjugates are produced via random
conjugation methods predicated on attaching bifunctional chelators to the lysines of …

Immune checkpoint inhibitors (ICIs) targeting the programmed cell death (ligand)-1 (PD-[L]
1) axis have emerged at the forefront of cancer treatment. 1 Numerous ICIs have received …

The synthesis of radioimmunoconjugates via the stochastic attachment of bifunctional
chelators to lysines can yield heterogeneous products with suboptimal in vitro and in vivo …