CNS targeting AAV vectors and methods of use thereof

G Gao, H Zhang, H Wang, Z Xu - US Patent 9,102,949, 2015 - Google Patents
The invention in some aspects relates to recombinant adeno-associated viruses useful for
targeting transgenes to CNS tissue, and compositions comprising the same, and methods of …

AAV's and uses thereof

G Gao, T Flotte, J Xie - US Patent 8,734,809, 2014 - Google Patents
The invention in some aspects relates to recombinant adeno-associated viruses having
distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer …

CNS targeting AAV vectors and methods of use thereof

G Gao, H Zhang, H Wang, Z Xu - US Patent 9,701,984, 2017 - Google Patents
US9701984B2 - CNS targeting AAV vectors and methods of use thereof - Google Patents
US9701984B2 - CNS targeting AAV vectors and methods of use thereof - Google Patents CNS …

Isolation of novel AAV'S and uses thereof

G Gao, PD Zamore - US Patent 9,217,155, 2015 - Google Patents
The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful
for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits …

AAV's and uses thereof

G Gao, T Flotte, J Xie - US Patent 9,284,357, 2016 - Google Patents
A6 IK 39/235(2006.01) 57 ABSTRACT CH2N 15/06)(2006.01)(57) CH2P 21/06(2006.01)
The invention in some aspects relates to recombinant adeno C07K 14/005(2006.01) …

Isolation of novel AAV's and uses thereof

G Gao, PD Zamore - US Patent 10,166,297, 2019 - Google Patents
The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful
for identifying adeno associated viruses in cells. In some aspects, the invention provides kits …

AAV-based treatment of cholesterol-related disorders

G Gao, PD Zamore, J Xie - US Patent 9,272,053, 2016 - Google Patents
The invention in some aspects relates to methods and compositions for assessing the
effectiveness of miRNA inhibitors. In other aspects of the invention, methods and …

Multicistronic expression constructs

G Gao, J Xie - US Patent 9,546,369, 2017 - Google Patents
6,156,303 A 12/2000 Russell et al. 1on provide mulucistronic nucleic acid constructs, Ior
6,251,677 B1 6/2001 Wilson et al. example, comprising an expression cassette encoding a …

Compositions for the treatment of disease

S Paul, DT Ward - US Patent 11,326,182, 2022 - Google Patents
The invention provides compositions and methods for the preparation, manufacture and
therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral …

Isolation of novel AAV's and uses thereof

G Gao, PD Zamore - US Patent 10,300,146, 2019 - Google Patents
The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful
for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits …