Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

The billions of proteins inside a eukaryotic cell are organized among dozens of sub-cellular
compartments, within which they are further organized into protein complexes. The …

We investigated how mitochondrial membrane proteins remain soluble in the cytosol until
their delivery to mitochondria or degradation at the proteasome. We show that Ubiquilin …

Cell division entails a sequence of processes whose specific demands for biosynthetic
precursors and energy place dynamic requirements on metabolism. However, little is known …

Nuclear DNA repair capacity is a critical determinant of cell fate under genotoxic stress
conditions. DNA repair is a well-defined energy-consuming process. However, it is unclear …

Mitochondria are the cellular energy hub and central target of metabolic regulation.
Mitochondria also facilitate proteostasis through pathways such as the 'mitochondria as …

Saturated fatty acids (SFAs)(the" bad" fat), especially palmitate (PA), in the human diet are
blamed for potential health risks such as obesity and cancer because of SFA-induced …

Mitochondria cannot be made de novo, so pre-existing mitochondria must be inherited at
each cell division. A new study demonstrates cell-cycle-dependent regulation of the activity …