Hepatoprotective effects of the long-acting fibroblast growth factor 21 analog PF-05231023 in the GAN diet-induced obese and biopsy-confirmed mouse model of …
Fibroblast growth factor 21 (FGF21) plays a key role in hepatic lipid metabolism and long-
acting FGF21 analogs have emerged as promising drug candidates for the treatment of …
acting FGF21 analogs have emerged as promising drug candidates for the treatment of …
Depletion of Igfbp7 alleviates zebrafish NAFLD progression through inhibiting hepatic ferroptosis
Y Wang, J Bo, Z Zhao, Y Han, Q Zhang, L Liu - Life Sciences, 2023 - Elsevier
Aims The global increased expression of Insulin-like growth factor binding protein 7
(IGFBP7) has been detected in non-alcoholic fatty liver disease (NAFLD) patients, however …
(IGFBP7) has been detected in non-alcoholic fatty liver disease (NAFLD) patients, however …
Integrative network-based analysis on multiple Gene Expression Omnibus datasets identifies novel immune molecular markers implicated in non-alcoholic …
J Zhang, Y Shen, X Chen, M Jiang, F Yuan… - Frontiers in …, 2023 - frontiersin.org
Introduction Non-alcoholic steatohepatitis (NASH), an advanced subtype of non-alcoholic
fatty liver disease (NAFLD), has becoming the most important aetiology for end-stage liver …
fatty liver disease (NAFLD), has becoming the most important aetiology for end-stage liver …
Ablation of IFNγ in myeloid cells suppresses liver inflammation and fibrogenesis in mice with hepatic small heterodimer partner (SHP) deletion
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common
complication of obesity and, in severe cases, progresses to metabolic dysfunction …
complication of obesity and, in severe cases, progresses to metabolic dysfunction …
Identification and validation of hub genes expressed in ulcerative colitis with metabolic dysfunction-associated steatotic liver disease
Y Liu, J Li, S Tian, Q Lan, Z Sun, C Liu… - Frontiers in …, 2024 - frontiersin.org
Objective Ulcerative colitis (UC) and metabolic dysfunction-associated steatotic liver disease
(MASLD) are closely intertwined; however, the precise molecular mechanisms governing …
(MASLD) are closely intertwined; however, the precise molecular mechanisms governing …
Integration of transcriptomic analysis and multiple machine learning approaches identifies NAFLD progression-specific hub genes to reveal distinct genomic patterns …
J Sun, R Shi, Y Wu, Y Lou, L Nie, C Zhang, Y Cao… - Journal of Big Data, 2024 - Springer
Background Nonalcoholic fatty liver disease (NAFLD) is a leading public health problem
worldwide. Approximately one fourth of patients with nonalcoholic fatty liver (NAFL) progress …
worldwide. Approximately one fourth of patients with nonalcoholic fatty liver (NAFL) progress …
Thy‐1 restricts steatosis and liver fibrosis in steatotic liver disease
V Blank, T Karlas, U Anderegg, J Wiegand… - Liver …, 2024 - Wiley Online Library
Abstract Background and Aims Steatotic liver disease (SLD) is generally considered to
represent a hepatic manifestation of metabolic syndrome and includes a disease spectrum …
represent a hepatic manifestation of metabolic syndrome and includes a disease spectrum …
Spatial and Single‐Cell Transcriptomics Reveals the Regional Division of the Spatial Structure of MASH Fibrosis
J Li, L Yang, M Xiao, N Li, X Huang, L Ye… - Liver …, 2023 - Wiley Online Library
Objective To elucidate the regional distribution of metabolic dysfunction‐associated
steatohepatitis (MASH) fibrosis within the liver and to identify potential therapeutic targets for …
steatohepatitis (MASH) fibrosis within the liver and to identify potential therapeutic targets for …
A novel gene-screening approach reveals QSOX1/IL1RAP as promising biomarkers for the severity of non-alcoholic fatty liver disease
W Ma, J Huang, B Cai, M Shao, X Yu, MB Kjær, M Lv… - medRxiv, 2023 - medrxiv.org
Abstract Background and Aims Non-alcoholic fatty liver disease (NAFLD) is a progressive
liver disease that ranges from simple steatosis to inflammation, fibrosis, and cirrhosis. To …
liver disease that ranges from simple steatosis to inflammation, fibrosis, and cirrhosis. To …
Identification of basement membrane genes and related molecular subtypes in nonalcoholic fatty liver disease
Z Wang, H Qin, Q Yang, J Jia, L Yang… - Hormone and …, 2023 - thieme-connect.com
Basement membranes (BMs) are widely distributed and highly specialized extracellular
matrix (ECM). The goal of this study was to explore novel genes associated with …
matrix (ECM). The goal of this study was to explore novel genes associated with …