Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted
protein degradation by the ubiquitin–proteasome system represent a new therapeutic …

Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad
biological processes through target-specific ubiquitylation. Our knowledge of this system …

Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

Induced protein degradation accomplishes elimination, rather than inhibition, of pathological
proteins. Key to the success of this novel therapeutic modality is the modification of proteins …

Type I collagen is the main component of bone matrix and other connective tissues.
Rerouting of its procollagen precursor to a degradative pathway is crucial for osteoblast …

Coat proteins play multiple roles in the life cycle of a membrane‐bound transport
intermediate, functioning in lipid bilayer remodeling, cargo selection and targeting to an …

We undertook a functional dissection of chromatin remodeler BAZ1B in neural crest (NC)
stem cells (NCSCs) from a uniquely informative cohort of typical and atypical patients …

Long noncoding RNAs (lncRNAs) have been demonstrated to be important regulators
during the osteogenic differentiation of mesenchymal stem cells (MSCs). We analyzed the …

Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …