BDNF as a mediator of antidepressant response: recent advances and lifestyle interactions

S Cubillos, O Engmann, A Brancato - International journal of molecular …, 2022 - mdpi.com
Conventional antidepressants are widely employed in several psychiatric and neurologic
disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are …

Canada's colonial genocide of Indigenous peoples: A review of the psychosocial and neurobiological processes linking trauma and intergenerational outcomes

K Matheson, A Seymour, J Landry, K Ventura… - International journal of …, 2022 - mdpi.com
The policies and actions that were enacted to colonize Indigenous Peoples in Canada have
been described as constituting cultural genocide. When one considers the long-term …

Loss of spines in the prelimbic cortex is detrimental to working memory in mice with early-life adversity

L Xu, Y Liu, J Long, X He, F Xie, Q Yin, M Chen… - Molecular …, 2023 - nature.com
Adverse experiences in early life can shape neuronal structures and synaptic function in
multiple brain regions, leading to deficits of distinct cognitive functions later in life. Focusing …

Early Life Stress and Major Depressive Disorder—An Update on Molecular Mechanisms and Synaptic Impairments

AG Bertollo, ACL Galvan, C Dallagnol, AD Cortez… - Molecular …, 2024 - Springer
Early life stress (ELS), characterized as abuse, neglect, and abandonment, can cause
several adverse consequences in the lives of affected individuals. ELS experiences can …

Outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats

L Rullo, LM Losapio, C Morosini, F Mottarlini… - Frontiers in Cellular …, 2023 - frontiersin.org
Social and emotional experiences differently shape individual's neurodevelopment inducing
substantial changes in neurobiological substrates and behavior, particularly when they …

[HTML][HTML] Sexual dimorphism in spatial learning and brain metabolism after exposure to a western diet and early life stress in rats

I López-Taboada, S Sal-Sarria, G Vallejo… - Physiology & …, 2022 - Elsevier
Prolonged daily intake of Western-type diet rich in saturated fats and sugars, and exposure
to early life stress have been independently linked to impaired neurodevelopment and …

Early life stress alters expression of glucocorticoid stress response genes and trophic factor transcripts in the rodent basal ganglia

CH Tran, C Shannon Weickert, TW Weickert… - International Journal of …, 2022 - mdpi.com
Early life stress shapes the developing brain and increases risk for psychotic disorders. Yet,
it is not fully understood how early life stress impacts brain regions in dopaminergic …

The effects of forced exercise and zinc supplementation during pregnancy on prenatally stress‐induced behavioral and neurobiological consequences in adolescent …

P Sameei, S Fatehfar, N Abdollahzadeh… - Developmental …, 2023 - Wiley Online Library
Prenatal manipulations can lead to neurobehavioral changes in the offspring. In this study,
individual and combined effects of forced exercise and zinc supplementation during …

Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and Rats

J Alpirez, LC Leon-Moreno, IG Aguilar-García… - Brain Sciences, 2023 - mdpi.com
Traumatic brain injury has been the leading cause of mortality and morbidity in human
beings. One of the most susceptible structures to this damage is the hippocampus due to …