The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events
including cell migration. Directional cell migration requires the polarization of both signaling …

The ubiquitous second messenger Ca2+ has long been recognized as a key regulator in
cell migration. Locally confined Ca2+, in particular, is essential for building front-to-rear …

MALAT1 is an oncogenic long non-coding RNA that has been found to promote the
proliferation of many malignant cell types and non-malignant human umbilical vein …

Processes that are important in cancer progression, such as sustained cell growth, invasion
to other organs, and resistance to cell death inducers, have a clear overlap with pathways …

Background Trastuzumab, a humanized antibody targeting HER2, exhibits remarkable
therapeutic efficacy against HER2-positive gastric cancer. However, recurrent therapeutic …

The changes in intracellular free calcium (Ca2+) levels are one of the most widely regulators
of cell function; therefore, calcium as a universal intracellular mediator is involved in very …

The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …

Abnormal activation of calcium channels has been shown to play crucial roles in tumor
occurrence and development. However, the role of inhibitors targeting calcium channels in …

The term metastasis is widely used to describe the endpoint of the process by which tumour
cells spread from the primary location to an anatomically distant site. Achieving successful …