Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

Skeletal muscle mass increases during postnatal development through a process of
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …

As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …

Skeletal muscle satellite cells are considered to play a crucial role in muscle fiber
maintenance, repair and remodeling. Our knowledge of the role of satellite cells in muscle …

Skeletal muscle adapts its mass as consequence of physical activity, metabolism and
hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the …

A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal
muscle mass and strength,. Although the etiology of sarcopenia is unknown, the correlation …

Skeletal muscle is the most abundant type of tissue in human body, being involved in
diverse activities and maintaining a finely tuned metabolic balance. Autophagy …

Rationale: Critical illness survivors often experience permanent functional disability due to
intensive care unit (ICU)-acquired weakness. The mechanisms responsible for long-term …

The largest mammalian cells are the muscle fibers, and they have multiple nuclei to support
their large cytoplasmic volumes. During hypertrophic growth, new myonuclei are recruited …