Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …

ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of
cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent …

The SARS-CoV-2 spike protein has been shown to disrupt blood–brain barrier (BBB)
function, but its pathogenic mechanism of action is unknown. Whether angiotensin …

A fundamental property of many plasma-membrane proteins is their association with the
underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and …

Cell Movements vividly describes how complex movements can arise from the properties
and behaviors of biological molecules. This second edition is updated throughout with …

Rho family GTPases regulate the actin and adhesion dynamics that control cell migration.
Current models postulate that Rac promotes membrane protrusion at the leading edge and …

Ezrin, radixin, and moesin (ERM) regulate cortical morphogenesis and cell adhesion by
connecting membrane adhesion receptors to the actin-based cytoskeleton. We have studied …

▪ Abstract Members of the Rho family of small Ras-like GTPases—including RhoA,-B, and-C,
Rac1 and-2, and Cdc42—exhibit guanine nucleotide-binding activity and function as …

Endothelial permeability depends on the integrity of intercellular junctions as well as
actomyosin-based cell contractility. Rho GTPases have been implicated in signalling by …

Abstract Ezrin, Radixin, and Moesin (the ERM proteins) supply regulated linkage between
membrane proteins and the actin cytoskeleton. The study of mammalian ERM proteins has …