Endoplasmic reticulum stress and lipids in health and diseases
The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …
ER stress and the unfolded protein response in neurodegeneration
The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …
alteration in the functionality of distinct neuronal populations. The pathology of many …
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …
molecular mechanisms involved in this process, such as autophagy, may contribute to …
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review
N Reich, C Hölscher - Frontiers in neuroscience, 2022 - frontiersin.org
Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …
The role of endoplasmic reticulum stress in human pathology
SA Oakes, FR Papa - Annual Review of Pathology: Mechanisms …, 2015 - annualreviews.org
Numerous genetic and environmental insults impede the ability of cells to properly fold and
posttranslationally modify secretory and transmembrane proteins in the endoplasmic …
posttranslationally modify secretory and transmembrane proteins in the endoplasmic …
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …
conditions and increased prevalence is of public concern. Recent research has provided …
Astrocyte unfolded protein response induces a specific reactivity state that causes non-cell-autonomous neuronal degeneration
HL Smith, OJ Freeman, AJ Butcher, S Holmqvist… - Neuron, 2020 - cell.com
Recent interest in astrocyte activation states has raised the fundamental question of how
these cells, normally essential for synapse and neuronal maintenance, become pathogenic …
these cells, normally essential for synapse and neuronal maintenance, become pathogenic …
Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation
J Kou, J Shi, Y He, J Hao, H Zhang, D Luo… - Acta Pharmacologica …, 2022 - nature.com
Luteolin is a flavonoid in a variety of fruits, vegetables, and herbs, which has shown anti-
inflammatory, antioxidant, and anti-cancer neuroprotective activities. In this study, we …
inflammatory, antioxidant, and anti-cancer neuroprotective activities. In this study, we …
Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …
millions of people worldwide. As the number of AD cases continues to increase in both …