The inositol phosphate signalling network in physiology and disease
Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
Summary Lymphocyte activation gene 3 (Lag3) is an inhibitory co-receptor expressed on
activated T cells and has been proposed to regulate regulatory T (Treg) cell function …
activated T cells and has been proposed to regulate regulatory T (Treg) cell function …
[HTML][HTML] Exploring the therapeutic potential of regulatory T cell in rheumatoid arthritis: Insights into subsets, markers, and signaling pathways
QY Su, HC Li, XJ Jiang, ZQ Jiang, Y Zhang… - Biomedicine & …, 2024 - Elsevier
Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease
characterized by an imbalance between immunological reactivity and immune tolerance …
characterized by an imbalance between immunological reactivity and immune tolerance …
Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity
M Jia, S Liu, Y Xiao, Z Zhang, M Li, X Qi, X Qi, L Yu… - Molecular …, 2024 - Elsevier
Objective Studies have shown a correlation between obesity and mitochondrial calcium
homeostasis, yet it is unclear whether and how Mcu regulates adipocyte lipid deposition …
homeostasis, yet it is unclear whether and how Mcu regulates adipocyte lipid deposition …
Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis
J Shen, F Li, X Han, D Fu, Y Xu, C Zhu, Z Liang… - Cell Communication and …, 2024 - Springer
Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its
exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly …
exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly …
A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex
Abstract Background Phospholipase C gamma 1 (PLCγ1) is an important mediator of the T
cell receptor (TCR) and growth factor signaling. PLCγ1 is activated by Src family kinases …
cell receptor (TCR) and growth factor signaling. PLCγ1 is activated by Src family kinases …
Lymphocyte activation gene 3 (Lag3) supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis
Abstract Lymphocyte activation gene 3 (Lag3) has emerged as the next-generation immune
checkpoint molecule due to its ability to inhibit effector T cell activity. Foxp3+ regulatory T …
checkpoint molecule due to its ability to inhibit effector T cell activity. Foxp3+ regulatory T …
Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
CM Yuk, D Kim, S Hong, M Kim, HW Jeong, SJ Park… - bioRxiv, 2024 - biorxiv.org
Activated proinflammatory T helper (Th) cells, such as Th1 and Th17 cells, mediate immune
responses against intra-and extra-cellular pathogens as well as cause the development of …
responses against intra-and extra-cellular pathogens as well as cause the development of …
[PDF][PDF] Deletion of the Mitochondrial Calcium Uniporter in Adipose Tissue Promotes Adipocyte Browning and Alleviates Diet-Induced Obesity
M Jia, Y Xiao, S Liu, Z Zhang, M Li, X Qi, X Qi, L Yu… - papers.ssrn.com
Obesity and associated diseases have become one of the most important public health
problems worldwide. The mitochondrial calcium uniporter (MCU) is an important transporter …
problems worldwide. The mitochondrial calcium uniporter (MCU) is an important transporter …