The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins
that provide protection for the chromosome terminus by blocking inappropriate …

Genome packaging by nucleosomes is a hallmark of eukaryotes. Histones and the pathways
that deposit, remove, and read histone modifications are deeply conserved. Yet, we lack …

Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of
the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the …

The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at
individual chromosome ends by the telomeric protein/DNA complex in a manner dependent …

The rapid evolution of telomere proteins has hindered identification of orthologs from diverse
species and created the impression that certain groups of eukaryotes have largely non …

Proteins that specifically bind the single-stranded overhang at the ends of telomeres have
been identified in a wide range of eukaryotes and play pivotal roles in chromosome end …

SR proteins are conserved RNA‐binding proteins best known as splicing regulators that
have also been implicated in other steps of gene expression. Despite mounting evidence for …

Telomeres and genes encoding 45S ribosomal RNA (rDNA) are frequently located adjacent
to each other on eukaryotic chromosomes. Although their primary roles are different, they …

Telomeres, as physical ends of linear chromosomes, are targets of a number of specific
proteins, including primarily telomerase reverse transcriptase. Access of proteins to the …