Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …

The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …

Despite considerable progress in pharmacotherapy over the past seven decades, many
mental disorders remain insufficiently treated. This situation is in part due to the limited …

Importance Insufficient treatment response and resulting chronicity constitute a major
problem in depressive disorders. Remission rates range as low as 15% to 40% and …

Background Indolent systemic mastocytosis (ISM) is a clonal mast-cell disease driven by the
KIT D816V mutation. We assessed the efficacy and safety of avapritinib versus placebo, both …

Disruption in reciprocal connectivity between the right anterior insula and the left
dorsolateral prefrontal cortex is associated with depression and may be a target for …

There is a growing literature exploring the placebo response within specific mental
disorders, but no overarching quantitative synthesis of this research has analyzed evidence …

Results: In total, 126 articles were included, encompassing 86 unique studies. Of studies
with a drug control condition (80), 49 (61.2%) used an inert placebo control, 16 (20.0%) …

Background Racemic ketamine is a mixture of (R)-ketamine (arketamine) and (S)-ketamine
(esketamine), with the latter regarded as the main isomer for antidepressant effects …